Nattokinase and berberine are two popular supplements that have gained attention for their potential health benefits. While they can be taken separately, some people consider combining them. Here's what you need to know about taking nattokinase and berberine supplements together:
Potential Benefits
Cardiovascular Health: Nattokinase is known for its potential to support healthy blood flow and maintain normal blood pressure. Berberine has been studied for its effects on lipid metabolism and cardiovascular health. Together, they might offer complementary benefits for heart health [2].
Blood Sugar Management: Berberine has shown promise in helping to regulate blood glucose levels [1]. While nattokinase doesn't directly affect blood sugar, its circulatory benefits might complement berberine's effects on metabolic health.
Anti-inflammatory Effects: Both supplements have been associated with anti-inflammatory properties, which could potentially enhance overall health when used in combination [3].
Considerations for Combined Use
Dosage: When taking both supplements, it's crucial to adhere to recommended dosages for each. Typically, nattokinase is taken in doses of 100-200 mg per day, while berberine dosages can range from 900-1500 mg daily, divided into 2-3 doses [4].
Timing: Consider taking nattokinase on an empty stomach for optimal absorption, while berberine is often recommended to be taken with meals to minimize potential gastrointestinal side effects [5].
Interaction with Medications: Both supplements can interact with certain medications. Nattokinase may enhance the effects of blood thinners, while berberine can interact with various drugs, including some diabetes medications [1].
Safety Precautions
Consult a Healthcare Provider: Before combining these supplements, it's essential to consult with a healthcare professional, especially if you have existing health conditions or are taking medications [2].
Monitor for Side Effects: Watch for any adverse reactions when starting this combination. Common side effects of nattokinase can include digestive discomfort, while berberine might cause diarrhea or constipation in some individuals [3].
Pregnancy and Breastfeeding: Both supplements should be avoided during pregnancy and breastfeeding unless specifically recommended by a healthcare provider [4].
Conclusion
While nattokinase and berberine supplements can potentially be taken together for their complementary health benefits, it's crucial to approach this combination with caution. Always prioritize professional medical advice, especially when considering multiple supplements. Proper dosing, timing, and awareness of potential interactions are key to safely incorporating these supplements into your health regimen [5].
References
1. Chen, W., et al. (2012). Berberine: A novel type 2 diabetes mellitus drug. Acta Pharmaceutica Sinica B, 2(4), 327-334. Link
2. Fujita, M., et al. (2011). Nattokinase: A promising alternative in prevention and treatment of cardiovascular diseases. Biomarker Insights, 6, BMI-S7156. Link
3. Lan, J., et al. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81. Link
4. Sumi, H., et al. (1987). A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia, 43(10), 1110-1111. Link
5. Zhang, Y., et al. (2008). Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes, 57(5), 1414-1418. Link
