Nattokinase IS POSSIBLY SAFE when taken by mouth as a medicine. Administering two doses of a specific product containing nattokinase (Flite Tabs) appears to be safe. However, it's not known if it's safe to take more than two doses. Nattokinase may help prevent blood clots, lower blood pressure, and play a role in treating Alzheimer's disease.
There is some preliminary evidence that nattokinase may have benefits for heart and artery health. A study shows that a nattokinase supplement reduces the risk of blood clots forming after long airplane flights. May help reduce narrowing of the arteries.