It seems premature to recommend the use of nattokinase in patients who are more willing to take it (as a substitute for warfarin, aspirin or clopidogrel). In addition, taking NK in combination with the above-mentioned medications may increase the risk of bleeding and should be avoided. If you take any medications regularly, talk to your doctor before starting to use nattokinase supplements. Supplements may interact with blood thinners and other drugs that reduce clotting, such as aspirin and ibuprofen.
They may cause excessive bleeding and bruising. The blood coagulation cascade has two sides. There is a formation of blood clots on one side. And on the other hand, there's the way our body breaks down blood clots once they're created. Unlike other anticoagulants such as aspirin, which only decrease the tendency to form blood clots, nattokinase affects both sides of the coagulation cascade.
Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Nattokinase is used as a health-promoting drug to prevent thrombosis due to its fibrinolytic activity. Not only that, volunteers who received nattokinase showed significant reductions in total cholesterol, low-density lipoprotein cholesterol (LDL-C or “bad cholesterol”) and triglycerides (TG), while, at the same time, their levels of high-density lipoprotein cholesterol (HDL-C or “good cholesterol”) increased. A study shows that a nattokinase supplement reduces the risk of blood clots after long plane flights.
More studies are needed to determine if nattokinase taken as a supplement is safe for repeated or long-term use. If you have a blood clotting disorder, don't take nattokinase supplements unless your doctor says they're safe. Nattokinase has the potential to simplify drug use and improve patient compliance with prevention and treatment. of cardiovascular diseases.
Because of the lack of safety testing, doctors do not recommend nattokinase to children or to women who are pregnant or breastfeeding. In a 26-week study, 82 volunteers were randomly assigned to take 6000 fibrinolytic units (300 mg) of nattokinase a day. We present the case of a patient who had used aspirin for the secondary prevention of a stroke and who suffered acute cerebellar bleeding after taking 400 mg of nattokinase a day for 7 consecutive days. It is suggested that nattokinase may increase the risk of intracerebral bleeding in patients who have cerebral microangiopathy prone to bleeding and are receiving other antithrombotic drugs by same time.
The benefits of nattokinase are likely due to the combined effect of nattokinase's ability to promote healthy blood clotting, its antioxidant properties, and its ability to maintain healthy lipids.
